PUBLISHED HUMAN RESEARCH
A trial in context.
Findings and boundaries.
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline.
SCHWARZ ET AL. / JAMA NETWORK OPEN / 2022
What was tested
| Study element | Published information |
|---|---|
| Design | Randomized, placebo-controlled clinical trial |
| Participants | 100 adults with subjective cognitive decline |
| Duration | 12 months |
| Preparation | Spermidine-rich dietary supplement extracted from wheat germ |
| Primary outcome | Change in mnemonic discrimination performance |
What the trial found
The primary memory outcome did not differ significantly between the supplement and placebo groups. Exploratory signals in other outcomes require further confirmation.
How to interpret it
This was not a Dr.SPD trial. Its preparation and study population limit direct transfer of the findings to a different ingredient grade or finished product. The study does not establish improved memory from Dr.SPD.
Read the original study recordSource: PubMed · PMID 35616942 ↗
Reviewed 27 October 2026. This page summarizes published evidence and is not a consumer dose recommendation.
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